Bioinspired Nanocomposites for Simultaneous Antimicrobial Action and Tissue Regeneration

Abstract

Bioinspired nanocomposites are a promising approach in biomedical engineering, combining antimicrobial properties and tissue regeneration capabilities. Mimicking natural extracellular matrices, they create an ideal environment for cell adhesion, growth, and differentiation, which accelerates tissue repair. Incorporating bioactive nanomaterials, such as antimicrobial peptides, metal oxides, or nano-silicates, gives these scaffolds strong antibacterial properties, which combat both Gram-positive and Gram-negative bacteria, thereby reducing the risk of implant infections. They also maintain high biocompatibility and mechanical strength for various tissue engineering applications, from bone to soft tissue. Recent advances have shown that these materials serve as barriers to microbes and promote bone and other tissue-specific differentiation, supporting tissue regeneration both in vitro and in vivo. Their combined antimicrobial and regenerative capabilities make bioinspired nanocomposites promising next-generation biomaterials for regenerative medicine.